Tiit Örd
Senior Researcher
A.I. Virtanen Institute for Molecular Sciences, Faculty of Health Sciences
Research groups
Projects
Publications
29/29 items-
Epigenetic drug screening identifies enzyme inhibitors A-196 and TMP-269 as novel regulators of sprouting angiogenesis
Beter, M.; Pulkkinen, HH.; Örd, T; Sormunen, A; Kilpeläinen, L; Dunford, JE; Kaikkonen, MU; Aavik, E; Laham-Karam, N; Oppermann, U; Laakkonen, JP; Ylä-Herttuala, S. 2025. Scientific reports. 15: . 1628 A1 Journal article (refereed), original research -
Single-cell RNA sequencing reveals sex differences in the subcellular composition and associated gene-regulatory network activity of human carotid plaques
Sukhavasi, Katyayani; Mocci, Giuseppe; Ma, Lijiang; Hodonsky, Chani J.; Diez Benevante, Ernest; Muhl, Lars; Liu, Jianping; Gustafsson, Sonja; Buyandelger, Byambajav; Koplev, Simon; Lendahl, Urban; Vanlandewijck, Michael; Singha, Prosanta; Örd, Tiit; Beter, Mustafa; Selvarajan, Ilakya; Laakkonen, Johanna P.; Väli, Marika; den Ruijter, Hester M.; Civelek, Mete; Hao, Ke; Ruusalepp, Arno; Betsholtz, Christer; Järve, Heli; Kovacic, Jason C.; Miller, Clint L.; Romanoski, Casey; Kaikkonen, Minna U.; Bj. 2025. Nature cardiovascular research. 4: 412–432 A1 Journal article (refereed), original research -
Coronary Artery Disease Risk Variant Dampens the Expression of CALCRL by Reducing HSF Binding to Shear Stress Responsive Enhancer in Endothelial Cells in Vitro
Selvarajan, Ilakya; Kiema, Miika; Huang, Ru Ting; Li, Jin; Zhu, Jiayu; Pölönen, Petri; Örd, Tiit; Õunap, Kadri; Godiwala, Mehvash; Golebiewski, Anna Kathryn; Ravindran, Aarthi; Mäklin, Kiira; Toropainen, Anu; Stolze, Lindsey K; Arce, Maximiliano; Magnusson, Peetra U; White, Stephen; Romanoski, Casey E; Heinäniemi, Merja; Laakkonen, Johanna P; Fang, Yun; Kaikkonen, Minna U. 2024. Arteriosclerosis, thrombosis, and vascular biology. 44: 1330-1345 A1 Journal article (refereed), original research -
Secreted Protein Profiling of Human Aortic Smooth Muscle Cells Identifies Vascular Disease Associations
Aherrahrou, Rédouane; Baig, Ferheen; Theofilatos, Konstantinos; Lue, Dillon; Beele, Alicia; Örd, Tiit; Kaikkonen, Minna U; Aherrahrou, Zouhair; Cheng, Qi; Ghosh, Saikat Kumar B; Karnewar, Santosh; Karnewar, Vaishnavi; Finn, Aloke V; Owens, Gary K; Joner, Michael; Mayr, Manuel; Civelek, Mete. 2024. Arteriosclerosis, thrombosis, and vascular biology. 44: 898-914 A1 Journal article (refereed), original research -
Single nucleus RNA-sequencing integrated into risk variant colocalization discovers 17 cell-type-specific abdominal obesity genes for metabolic dysfunction-associated steatotic liver disease
Lee, Seung Hyuk T; Garske, Kristina M; Arasu, Uma Thanigai; Kar, Asha; Miao, Zong; Alvarez, Marcus; Koka, Amogha; Darci-Maher, Nicholas; Benhammou, Jihane N; Pan, David Z; Örd, Tiit; Kaminska, Dorota; Männistö, Ville; Heinonen, Sini; Wabitsch, Martin; Laakso, Markku; Agopian, Vatche G; Pisegna, Joseph R; Pietiläinen, Kirsi H; Pihlajamäki, Jussi; Kaikkonen, Minna U; Pajukanta, Päivi. 2024. EBioMedicine. 106: . 105232 A1 Journal article (refereed), original research -
Single-Cell Gene-Regulatory Networks of Advanced Symptomatic Atherosclerosis
Mocci, Giuseppe; Sukhavasi, Katyayani; Örd, Tiit; Bankier, Sean; Singha, Prosanta; Arasu, Uma Thanigai; Agbabiaje, Olayinka Oluwasegun; Mäkinen, Petri; Ma, Lijiang; Hodonsky, Chani J; Aherrahrou, Redouane; Muhl, Lars; Liu, Jianping; Gustafsson, Sonja; Byandelger, Byambajav; Wang, Ying; Koplev, Simon; Lendahl, Urban; Owens, Gary; Leeper, Nicholas J; Pasterkamp, Gerard; Vanlandewijck, Michael; Michoel, Tom; Ruusalepp, Arno; Hao, Ke; Ylä-Herttuala, Seppo; Väli, Marika; Järve, Heli; Mokry, Michal; C. 2024. Circulation research. 134: 1405-1423 A1 Journal article (refereed), original research -
Transcriptomic and spatial dissection of human ex vivo right atrial tissue reveals proinflammatory microvascular changes in ischemic heart disease
Linna-Kuosmanen, Suvi; Schmauch, Eloi; Galani, Kyriakitsa; Ojanen, Johannes; Boix, Carles A; Örd, Tiit; Toropainen, Anu; Singha, Prosanta K; Moreau, Pierre R; Harju, Kristiina; Blazeski, Adriana; Segerstolpe, Åsa; Lahtinen, Veikko; Hou, Lei; Kang, Kai; Meibalan, Elamaran; Agudelo, Leandro Z; Kokki, Hannu; Halonen, Jari; Jalkanen, Juho; Gunn, Jarmo; MacRae, Calum A; Hollmén, Maija; Hartikainen, Juha EK; Kaikkonen, Minna U; García-Cardeña, Guillermo; Tavi, Pasi; Kiviniemi, Tuomas; Kellis, Manolis. 2024. Cell reports medicine. 5: . 101556 A1 Journal article (refereed), original research -
Translatome profiling reveals Itih4 as a novel smooth muscle cell–specific gene in atherosclerosis
Ravindran, Aarthi; Holappa, Lari; Niskanen, Henri; Skovorodkin, Ilya; Kaisto, Susanna; Beter, Mustafa; Kiema, Miika; Selvarajan, Ilakya; Nurminen, Valtteri; Aavik, Einari; Aherrahrou, Rédouane; Pasonen-Seppänen, Sanna; Fortino, Vittorio; Laakkonen, Johanna P; Ylä-Herttuala, Seppo; Vainio, Seppo; Örd, Tiit; Kaikkonen, Minna U. 2024. Cardiovascular research. 120: 869-882 A1 Journal article (refereed), original research -
ApoA-I Nanotherapy Rescues Postischemic Vascular Maladaptation by Modulating Endothelial Cell and Macrophage Phenotypes in Type 2 Diabetic Mice
Babu, Mohan; Devi, Durga; Mäkinen, Petri; Örd, Tiit; Aavik, Einari; Kaikkonen, Minna; Ylä-Herttuala, Seppo. 2023. Arteriosclerosis, thrombosis, and vascular biology. 43: e46–e61 A1 Journal article (refereed), original research -
Cross-tissue omics analysis discovers ten adipose genes encoding secreted proteins in obesity-related non-alcoholic fatty liver disease
Darci-Maher, Nicholas; Alvarez, Marcus; Arasu, Uma Thanigai; Selvarajan, Ilakya; Lee, Seung Hyuk T.; Pan, David Z.; Miao, Zong; Das, Sankha Subhra; Kaminska, Dorota; Örd, Tiit; Benhammou, Jihane N.; Wabitsch, Martin; Pisegna, Joseph R.; Männistö, Ville; Pietiläinen, Kirsi H.; Laakso, Markku; Sinsheimer, Janet S.; Kaikkonen, Minna U.; Pihlajamäki, Jussi; Pajukanta, Päivi. 2023. EBioMedicine. 92: A1 Journal article (refereed), original research